A story at the Los Angeles Times reports that researchers at the Max Planck Institute have found that Selective Serotonin Reuptake Inhibitors, various of which are widely used in anti-depressant medications, cause changes in healthy subjects' brain architecture just hours after ingestion. As the article mentions, one reason that this rapid change is surprising is that patients taking SSRIs to treat depression typically take considerably longer (weeks) to perceive a change in mood. A slice from the story: When more serotonin was available, this resting state functional connectivity decreased on a broad scale, the study found. This finding was not particularly surprising -- other studies have shown a similar effect in brain regions strongly associated with mood regulation. But there was a two-fold shock: Some areas of the brain appeared to buck the trend and become more interdependent. And all the changes were evident only three hours after the single dosage. ... The rapid connectivity shifts noted by the study might therefore be precursors to longer-term changes, perhaps starting with remodeling of synapses, the microscopic gaps where chemical neurotransmitters such as serotonin flood across to an adjacent brain cell, the study suggests. But this type of brain scanning can’t pick up changes at such a scale, so the hypothesis will have to be tested other ways[.] ... Study subjects did not have diagnoses of depression, so researchers will need to generate similar maps among those diagnosed with depression, and re-map them during and after depressive episodes, as well as after treatment, Sacher said. Comparisons might then show whether a certain initial architecture predicts treatment success.
Read more of this story at Slashdot.