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CRISPR Eliminates HIV In Live Animals

Slashdot - Wed, 03/05/2017 - 7:00am
Researchers from the Lewis Katz School of Medicine at Temple University and the University of Pittsburgh show that HIV-1 infections can be eliminated from the genomes of living animals. Findings from the study have been published in the journal Molecular Therapy. Genetic Engineering and Biotechnology News reports: This is the first study to demonstrate that HIV-1 replication can be completely shut down and the virus eliminated from infected cells in animals with a powerful gene-editing technology known as CRISPR/Cas9. The new work builds on a previous proof-of-concept study that the team published in 2016, in which they used transgenic rat and mouse models with HIV-1 DNA incorporated into the genome of every tissue of the animals' bodies. They demonstrated that their strategy could delete the targeted fragments of HIV-1 from the genome in most tissues in the experimental animals. In this new study, the LKSOM team genetically inactivated HIV-1 in transgenic mice, reducing the RNA expression of viral genes by roughly 60% to 95% -- confirming their earlier findings. They then tested their system in mice acutely infected with EcoHIV, the mouse equivalent of human HIV-1. In the third animal model, a latent HIV-1 infection was recapitulated in humanized mice engrafted with human immune cells, including T cells, followed by HIV-1 infection. "These animals carry latent HIV in the genomes of human T cells, where the virus can escape detection," Dr. Hu explained. Amazingly, after a single treatment with CRISPR/Cas9, viral fragments were successfully excised from latently infected human cells embedded in mouse tissues and organs.

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Big Blue to buy Verizon's cloud

El Reg - Wed, 03/05/2017 - 6:30am
Just last year Verizon said it was investing for the long haul, now it will share with IBM

In February 2016 Verizon told The Register it “remains committed to delivering a range of cloud services for enterprise and government customers and is making significant investments in its cloud platform in 2016."…

Windows 10 S: Good, bad, and how this could get ugly for PC makers

El Reg - Wed, 03/05/2017 - 6:02am
Surface team roped in for not-for-students laptop

Analysis  Tuesday’s launch of Windows 10 S, a cut-down version of the operating system designed for the education market, has raised some interesting questions about Microsoft’s ongoing efforts to hit Google and Apple where it hurts.…

Mozilla takes a turn slapping Symantec's certification SNAFU

El Reg - Wed, 03/05/2017 - 5:27am
Take Google's advice and get out of CA infrastructure'

Mozilla has weighed in to the ongoing Symantec-Google certificate spat, telling Symantec it should follow the Alphabet subsidiary's advice on how to restore trust in its certificates.…

Apple blocks comms-snooping malware

El Reg - Wed, 03/05/2017 - 5:00am
Leaked developer certificate revoked, protection updated

Apple has moved to thwart a malware attack that used a legitimate – probably hijacked – developer certificate, by revoking the cert.…

Oracle links to LinkedIn so its salesware can sniff you out

El Reg - Wed, 03/05/2017 - 4:00am
Big Red wants One Profile To Rule Them All so marketers know what to sell you

Your LinkedIn profile just got a little bit more useful … for marketers, because Oracle has done a deal with Microsoft's social network.…

Trump Administration Rolls Back Obama-Era Nutrition Standards For School Lunches

Slashdot - Wed, 03/05/2017 - 3:30am
An anonymous reader quotes a report from Ars Technica: Just a week into his position, U.S. Secretary of Agriculture Sonny Perdue announced Monday a rollback of nutrition standards for school meals, previously championed by former First Lady Michelle Obama as part of a larger initiative to improve the health of America's children. Under Perdue's new rollback, schools across the country can now delay a requirement to reduce sodium levels, can serve kids fewer whole grains, and can provide one percent flavored milk in addition to flavored skim, unflavored skim, and unflavored one percent. In a news release that declared the move would "make school meals great again," Perdue said: "This announcement is the result of years of feedback from students, schools, and food service experts about the challenges they are facing in meeting the final regulations for school meals. If kids aren't eating the food, and it's ending up in the trash, they aren't getting any nutrition -- thus undermining the intent of the program." Specifically, under Obama-era nutrition rules, schools were supposed to decrease sodium from meals in three phases. For instance, 2012 school lunches had average sodium levels between roughly 1,400mg to 1,600mg, with elementary school lunches on the lower end. Federal dietary guidelines, which schools must follow, recommend kids get 1,900mg to 2,300mg or less of sodium per day (depending on age). Currently, schools have dropped down to "Target 1," which is a range of about 1,200mg to 1,400mg or less. Schools were supposed to get that down to about 900mg to 1,000mg this year ("Target 2") and then to between 600mg and 700mg by 2022 ("Final Target"). The USDA will now waive the requirement to reach Target 2 until 2020. The USDA will also grant exemptions from the current requirement for schools to serve only whole-grain-rich foods.

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135 MEELLION Indian government payment card details leaked

El Reg - Wed, 03/05/2017 - 2:58am
Legislation coming to beef up Aadhaar card privacy, security

If you're enthused about governments operating large-scale online identity projects, here's a cautionary tale: the Indian government's eight-year-old Aadhaar payment card project has leaked a stunning 130 million records.…

Cloud and DevOps getting you down? Here's how IT teams can join the party

El Reg - Wed, 03/05/2017 - 2:20am
Learn how to add value to digital business at Gartner's IT Infrastructure, Operations & Data Center Summit

Promo  Infrastructure and operations teams are copping criticism from two sources these days: developers want on-premises IT to behave and scale like a public cloud; line of business people expect all software to deliver an any-device, 50-more-users-NOW SaaS experience.…

How would you pronounce 'Cyxtera'?

El Reg - Wed, 03/05/2017 - 2:00am
We're asking because that's what CenturyLink's former data centres are called now

How would you pronounce 'Cyxtera'?…

Wine-Staging 2.7 Released With Latest Experimental Patches

Phoronix - Wed, 03/05/2017 - 1:44am
Building off last week's Wine 2.7 release is now an updated Wine-Staging...

Qubes kicks Xen while it's down after finding 'fatal, reliably exploitable' bug

El Reg - Wed, 03/05/2017 - 1:00am
You left the stable door open? AGAIN? C'mon guys, keep those guests locked up

Qubes is once again regretting how long it's taken to abandon Xen's PV hypervisor, disclosing another three bugs including host escape vulnerabilities.…

18-Year-Old Mexican Student Designs Bra That Can Detect Breast Cancer

Slashdot - Wed, 03/05/2017 - 1:00am
An 18-year-old student from Mexico has won the top prize at the Global Student Entrepreneur Awards (GSEA) for his invention of a bra that can help in the early detection of breast cancer. "The bra, otherwise known as EVA, was developed with three friends through his company Higia Technologies, and was created primarily for women with genetic predisposition to cancer," reports The Independent. From the report: Equipped with around 200 biosensors, the bra maps the surface of the breast and is able to monitor changes in temperature, shape and weight. "Why a bra? Because it allows us to have the breasts in the same position and it doesn't have to be worn more than one hour a week," he said in an interview with El Universal. Rios Cantu says that the biosensors are able to determine thermal conductivity by specific zones. In some instances, heat can indicate more blood flow, which therefore indicates that those blood vessels are "feeding" on something -- typically some type of cancer. After beating 13 other student entrepreneurs from around the globe, Rios Cantu took home an impressive $20,000.

Read more of this story at Slashdot.

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